Optical sensor concepts for monitoring metabolic activity
New optical sensor concepts for monitoring metabolic activity in Organ-on-Chips
This subproject will investigate new sensor concepts for lactate, potassium and reactive oxygen species and transfer to Organ-on-Chips devices. Sensor concepts are based on the enzyme catalysed conversion of the target analytes and the determination of consumed oxygen or changes of pH by integrated optical sensors. Microfluidic systems are fabricated capable of integrating sensors, immobilising enzymes and adding of reagents. The new sensors will complement sensors for oxygen, pH and glucose and enable the in depth analysis of the metabolic activity of biological models on the exposure of drugs and nanomaterials.