Gut-on-a-chip modelling microbiome dysbiosis
We will mimic a mini-microbiome of the gut by emulating colonization with commensal strains and complex microbial derived metabolite mixtures simulating healthy and dysbiotic conditions. In particular, we will focus on the role of short chain fatty acids in shaping the stem cell niche and orchestrating the immune response to the microbiome.
A human microbiome model will be available that allows detailed functional analysis of host-microbiome interaction on the cellular and molecular level in human gut-on-chip. The model will be suitable for testing of drugs targeting microbiome composition and evaluation of immune response and barrier maintenance.