5. Project - We are hiring!

Emulation of the human gut in an integrated microfluidic organ-on-chip platform for investigation of human microbiome host interactions

Recruiting organisation:
Jena University Hospital / INSPIRE Lab (PI: Dr. Alexander Mosig)

Starting date:
01.03.2021

Job Description:
The advertised subproject will be carried out by a Research Assistant (“Early-stage Researcher”) at Jena University Hospital over a period of 19 months, with the option to extend funding for a total of 36 months to do a PhD thesis. The recruited researcher will work in the INSPIRE Lab headed by Asst. Prof. Dr. Alexander Mosig, at the Center for Sepsis Control and Care / Institute of Biochemistry II.

She/he will develop and apply a novel Organ-on-a-chip system emulating an immunocompetent model of the human gut

  1. by bioengineering of hiPSC derived tissues emulating organotypic microphysiological conditions of the human gut;
  2. to establish a physiological model of the human microbiome colonizing the gut-on-chip model;
  3. to study physiological host-microbiome interaction at the cellular and molecular level under physiological and disease related conditions

Secondments are planned as follows:

  • Universite du Luxembourg (Luxembourg) for 1 month;
  • Transgene SA (France) for 1 month;
  • INSERM, University Nantes (France) for 1 month.

This subproject is fully funded by the Marie Skłodowska-Curie European Training Network „EUROoC“ (H2020-MSCA-ITN-2018). The monthly salary consists of a living allowance, mobility allowance and family allowance (if applicable). Please visit the EC MSCA webpage for more information. The recruited researcher will have the opportunity to work as part of an international, interdisciplinary team of 15 PhD students, based at universities and industrial firms throughout Europe. She/he will gain a unique skill-set comprising microfabrication, biomaterial science and stem cell differentiation, as well as an overview of different organ-on-a-chip technologies and their implementation at industrial level. She/He is expected to disseminate the results through patents (if applicable), publications in peer-reviewed journals and presentations at international conferences.

Requirements: 

  • Early-stage researcher: a researcher without a PhD, who is in the first four years (full-time equivalent research experience) of her/his research career, measured from the date when she/he obtained the degree, which would formally entitle her/him to embark on a doctorate.
  • Mobility: The applicant must not have resided or carried out her/his main activity (work, studies etc.) in Germany for more than 12 months in the past three years.
  • Graduation in the field of biology, microbiology, biomedical engineering or related fields (M.Sc. preferred).
  • Basic knowledge of cell culture, bioengineering, 3D cell models
  • Practical experience of stem cell culture & differentiation and fluorescence microscopy is a plus.
  • Basic knowledge of data and image analysis and Microsoft Office.
  • Well-structured and autonomous working style, good organizational and communication skills.
  • Fluency in written and spoken English is a must, German is a plus.

How to apply:
Please send your CV, a half-page summary of master/diploma thesis, a letter of motivation (up to 2 pages) which states your research experience and interests, and names and contact information of at least two academic referees who could write a letter of recommendation by e-mail to the following address, quoting the reference „EUROoC-JUH-ESR5“: EUROoC@igb.fraunhofer.de.

For questions, please contact:
Dr. Alexander Mosig
alexander.mosig@med.uni-jena.de

Application deadline:
3rd January 2021
Interviews are planned for February 2021.

Please find the full job posting with more information here:
PhD Position for EUROoC Project (Marie Skłodowska-Curie European Training Network)