Host Organisation: Jena University Hospital, Germany
INSPIRE Lab (PI: Dr. Alexander Mosig)
Project Title: Emulation of the human gut in an integrated microfluidic organ-on-chip platform for investigation of human microbiome host interactions.
- Bioengineering of hiPSC derived tissues emulating organotypic microphysiological conditions of the human gut;
- Establish a physiological model of the human microbiome colonizing the gut-on-chip model;
- Study physiological host-microbiome interactions at the cellular level as well as pathophysiological alterations of these mechanisms in the context of human dysbiosis and infection.