ESR 5

Name: 

Host Organisation: Jena University Hospital, Germany

INSPIRE Lab (PI: Dr. Alexander Mosig)

Project Title: Emulation of the human gut in an integrated microfluidic organ-on-chip platform for investigation of human microbiome host interactions.

Objectives of the Project

  1. Bioengineering of hiPSC derived tissues emulating organotypic microphysiological conditions of the human gut;
  2. Establish a physiological model of the human microbiome colonizing the gut-on-chip model;
  3. Study physiological host-microbiome interactions at the cellular level as well as pathophysiological alterations of these mechanisms in the context of human dysbiosis and infection.
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