Uppsala University, Sweden
EMBLA Group (PI: Dr. Maria Tenje)
Microfluidic methods for bead-based assays on-chip
The advertised subproject will be carried out by a PhD student (“Early-stage Researcher”) at Uppsala University over a period of 42-48 months, in addition departmental duties at a level of at most 20% (typically teaching) will be expected. The recruited researcher will work in the EMBLA Group headed by Dr. Maria Tenje, which develops microsystems for applications within the life sciences with a special interest on research related to micro/nano fabrication and processing of new materials.
She/he will develop a microfluidic manipulation method to introduce, incubate, elute and analyse microbeads for cytokine detection in low volumes.
The main working tasks of the advertised subproject are to:
- develop a bead manipulation unit based on acoustic trapping;
- integrate the bead manipulations method with organ models developed by other project partners;
- perform and characterise immunoassays on-chip using the developed platform.
Secondments are planned as follows:
- Miltenyi Biotec GmbH, Germany for 2 months;
- Universitaet Bern, Switzerland for 3 months;
- Universite du Luxembourg, Luxembourg for 2 months;
- Fraunhofer Gesellschaft zur Foerderung der angewandten Forschung e.V., Germany for 2 months.
This subproject is fully funded by the Marie Skłodowska-Curie European Training Network „EUROoC“ (H2020-MSCA-ITN-2018). The monthly salary consists of a living allowance, mobility allowance and family allowance (if applicable). Please visit the EC MSCA webpage for more information. The recruited researcher will have the opportunity to work as part of an international, interdisciplinary team of 15 PhD students, based at universities and industrial firms throughout Europe. She/he will gain a unique skill-set comprising microfabrication, biomaterial science and stem cell differentiation, as well as an overview of different organ-on-a-chip technologies and their implementation at industrial level. She/he is expected to finish the project with a PhD thesis and to disseminate the results through patents (if applicable), publications in peer-reviewed journals and presentations at international conferences.
Marie Skłodowska-Curie European Training Networks (ETNs) are joint research and training projects funded by the European Union. Funding is provided for PhD students from both inside and outside Europe to carry out individual project work in a European country other than their own.
The European training network “EUROoC” is made up of 11 core and 10 associate partners from academia, industry and regulatory agencies, coordinated by Fraunhofer IGB. The network will recruit a total of 15 PhD students for project work lasting for 36 months.
Organ-on-a-Chip (OoC) technology is advancing at breath taking pace due to its potential impact in drug development and personalised treatments of disease. New researchers entering this field must be equipped with a multidisciplinary background ranging from biology to microfluidic chip engineering. EUROoC offers the first complete and coherent European training program on OoC by gathering multidisciplinary participants (biologists, physicists, chemists, engineers) in a multi-sectoral network composed of six companies, three regulation entities and twelve academic institutions.
EUROoC will qualify the next generation of interdisciplinary scientists for all aspects of OoC development and utilisation, including understanding of commercialisation pathways and regulatory aspects. EUROoC furthermore comprises a collection of innovative research projects addressing the development of advanced OoC systems with higher physiological significance going beyond current in vitro testing.
Qualifications / experience
- Early-stage researcher: a researcher without a PhD, who is in the first four years (full-time equivalent research experience) of her/his research career, measured from the date when she/he obtained the degree, which would formally entitle her/him to embark on a doctorate.
- Graduation in the field of engineering sciences, material science, nanotechnology, biomedical engineering or related fields – M.Sc. preferred.
- Basic knowledge of microfabrication, integrated acoustics, chip-to-world interfacing,
- Practical experience of PDMS moulding, LabView programming and fluorescence microscopy is a plus.
- Basic knowledge of data analysis and Microsoft Office.
- Well-structured and autonomous working style, good organizational and communication skills.
- Fluency in written and spoken English is a must.
The applicant must not have resided or carried out her/his main activity (work, studies etc.) in Sweden for more than 12 months in the past three years.
How to apply
Please send your CV, a half-page summary of master/diploma thesis, a letter of motivation (up to 2 pages) which states your research experience and interests, and names and contact information of at least two academic referees who could write a letter of recommendation by e-mail to the following address, quoting the reference „EUROoC-IGB-ESR8“:EUROoC@igb.fraunhofer.de
For questions, please contact:
Dr. Maria Tenje:
Uppsala University aims for gender balance and diversity in all activities in order to achieve a higher quality at all levels of the organization. We therefore welcome applicants of any gender and with different birth background, functionality and life experience.
Assessment of applications starts 31st January 2019, applications are possible until 17th February 2019.
Interviews are planned for February/ March 2019.